(19)

(11)

EP 0 868 195 A2

(12)

(43) Date of publication: 07.10.1998 Bulletin 1998/41 (21) Application number: 96943208.0 (22) Date of filing: 20.12.1996

(51) International Patent Classification (IPC):  C12Q 1/ 48( . ) A61K 38/ 00( . ) A61P 3/ 08( . ) A61P 35/ 00( . ) C12N 9/ 12( . ) A61K 31/ 00( . ) A61P 3/ 00( . ) A61P 3/ 10( . ) C07K 7/ 06( . ) (86) International application number: PCT/GB1996/003186 (87) International publication number: WO 1997/022360 (26.06.1997 Gazette 1997/27)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 20.12.1995 GB 19950026083 16.05.1996 GB 19960010272 18.07.1996 GB 19960015066 (71) Applicants: MEDICAL RESEARCH COUNCIL London W1N 4AL (GB) University of Dundee Dundee DD1 4HN, Scotland (GB)	(72) Inventors: COHEN, Philip Dundee DD2 5DQ (GB) ALESSI, Dario Dundee DD4 6NJ (GB) CROSS, Darren Dundee DD4 7E7 (GB) (74) Representative: Bassett, Richard Simon  Eric Potter Clarkson, Park View House, 58 The Ropewalk Nottingham NG1 5DD Nottingham NG1 5DD (GB)