(19)

(11)

EP 0 868 426 A1

(12)

(43) Date of publication: 07.10.1998 Bulletin 1998/41 (21) Application number: 97935012.0 (22) Date of filing: 18.07.1997

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C12N 1/ 19( . ) C12N 15/ 82( . ) C07K 14/ 415( . ) C12N 5/ 10( . ) C12Q 1/ 68( . ) (86) International application number: PCT/US1997/012626 (87) International publication number: WO 1998/003536 (29.01.1998 Gazette 1998/04)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 23.07.1996 US 19960027228P (71) Applicant: Novartis AG 4058 Basel (CH)	(72) Inventors: LEBEL, Edouard, Guillaume Durham, NC 27713 (US) RYALS, John, Andrew Cary, NC 27511 (US) THORNE, Leigh Raleigh, NC 27606 (US) UKNES, Scott, Joseph Apex, NC 27502 (US) WARD, Eric, Russell Durham, NC 27705 (US) (74) Representative: Bastian, Werner Maria, et al  Novartis AG Geistiges Eigentum Konzern Patent- und Markenabteilung CH Postfach 4002 Basel 4002 Basel (CH)