(19)

(11)

EP 0 868 430 A1

(12)

(43) Date of publication: 07.10.1998 Bulletin 1998/41 (21) Application number: 96941537.0 (22) Date of filing: 20.12.1996

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 38/ 00( . ) A61P 35/ 00( . ) A61P 37/ 02( . ) C07K 14/ 39( . ) C07K 14/ 47( . ) A61K 31/ 00( . ) A61P 31/ 00( . ) A61P 37/ 00( . ) A61P 43/ 00( . ) C07K 14/ 435( . ) (86) International application number: PCT/AU1996/000827 (87) International publication number: WO 1997/023501 (03.07.1997 Gazette 1997/29)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV RO SI (30) Priority: 22.12.1995 AU 1995PN07275 (71) Applicant: Amrad Operations Pty.,Ltd. Kew, VIC 3101 (AU)	(72) Inventor: VAUX, David, Laurence Fairfield, VIC 3078 (AU) (74) Representative: Jones, Elizabeth Louise  Frank B. Dehn & Co., 179 Queen Victoria Street London EC4V 4EL London EC4V 4EL (GB)