(19)

(11)

EP 0 869 818 A1

(12)

(43) Date of publication: 14.10.1998 Bulletin 1998/42 (21) Application number: 96944114.0 (22) Date of filing: 27.12.1996

(51) International Patent Classification (IPC):  A61K 31/ 00( . ) A61K 31/ 396( . ) A61K 31/ 5375( . ) A61K 38/ 00( . ) A61K 38/ 44( . ) A61K 45/ 00( . ) A61P 35/ 00( . ) A61K 31/ 395( . ) A61K 31/ 535( . ) A61K 31/ 538( . ) A61K 38/ 43( . ) A61K 39/ 395( . ) A61K 47/ 48( . ) (86) International application number: PCT/GB1996/003254 (87) International publication number: WO 1997/024143 (10.07.1997 Gazette 1997/30)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 29.12.1995 US 19950009361P 02.02.1996 CA 19962168680 (71) Applicant: AEPACT Limited London WC1E 6HQ (GB)	(72) Inventors: BAGSHAWE, Kenneth, Dawson London W1H 5TA (GB) BURKE, Philip, John Charlton London SE7 7PF (GB) (74) Representative: Bassett, Richard Simon  Eric Potter Clarkson, Park View House, 58 The Ropewalk Nottingham NG1 5DD Nottingham NG1 5DD (GB)