(19)
(11) EP 0 869 943 A1

(12)

(43) Date of publication:
14.10.1998 Bulletin 1998/42

(21) Application number: 96943110.0

(22) Date of filing: 04.12.1996
(51) International Patent Classification (IPC): 
A61K 31/ 00( . )
A61K 31/ 397( . )
A61P 3/ 10( . )
A61P 9/ 10( . )
A61P 19/ 02( . )
A61P 29/ 00( . )
C07D 205/ 08( . )
C07D 405/ 12( . )
A61K 31/ 395( . )
A61P 3/ 00( . )
A61P 9/ 00( . )
A61P 19/ 00( . )
A61P 25/ 18( . )
A61P 43/ 00( . )
C07D 205/ 09( . )
(86) International application number:
PCT/EP1996/005587
(87) International publication number:
WO 1997/021675 (19.06.1997 Gazette 1997/26)
(84) Designated Contracting States:
BE CH DE ES FR GB IT LI NL

(30) Priority: 08.12.1995 GB 19950025131
15.11.1996 GB 19960023756

(71) Applicant: SMITHKLINE BEECHAM PLC
Brentford, Middlesex TW8 9EP (GB)

(72) Inventors:
  • HICKEY, Deirdre, M.B.- SmithKline Beecham Pharm.
    Harlow, Essex CM19 5AW (GB)
  • DHANAK, Dashyant-SmithKline Beecham Pharmaceutic.
    Collelegeville, PA 19426-0989 (US)
  • IFE, Robert, John-SmithKline Beecham Pharmaceutic
    Harlow, Essex CM 19 5AW (GB)
  • LEACH, Colin Andrew, SmithKline Beecham Pharmac.
    Harlow, Essex CM 19 5AW (GB)
  • TEW, David, Graham, SmithKline Beecham Pharmac.
    Harlow, Essex CM 19 5AW (GB)

(74) Representative: Connell, Anthony Christopher, et al 
SmithKline Beecham plc Corporate Intellectual Property, Two New Horizons Court
Brentford, Middlesex TW8 9EP
Brentford, Middlesex TW8 9EP (GB)

   


(54) MONOCYCLIC BETA-LACTAME DERIVATIVES FOR TREATMENT OF ATHEROSCLEROSIS