(19)

(11)

EP 0 869 972 A1

(12)

(43) Date of publication: 14.10.1998 Bulletin 1998/42 (21) Application number: 96940487.0 (22) Date of filing: 15.11.1996

(51) International Patent Classification (IPC):  G01N 33/ 53( . ) A61K 31/ 70( . ) A61K 45/ 00( . ) A61P 3/ 00( . ) A61P 31/ 00( . ) A61P 43/ 00( . ) C12N 15/ 09( . ) C12Q 1/ 68( . ) A61K 31/ 00( . ) A61K 38/ 00( . ) A61K 48/ 00( . ) A61P 3/ 10( . ) A61P 37/ 00( . ) C07K 14/ 52( . ) C12P 21/ 02( . ) C12R 1/ 19( . ) (86) International application number: PCT/US1996/018398 (87) International publication number: WO 1997/018237 (22.05.1997 Gazette 1997/22)

(84) Designated Contracting States: BE DE ES FR GB IT NL (30) Priority: 15.11.1995 US 19950006809P 01.12.1995 US 19950566334 (71) Applicant: Incyte Pharmaceuticals, Inc. Palo Alto, CA 94304 (US)	(72) Inventors: COLEMAN, Roger Mountain View, CA 94041 (US) BANDMAN, Olga Mountain View, CA 94043 (US) (74) Representative: Goldin, Douglas Michael  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)