(19)

(11)

EP 0 871 392 A1

(12)

(43) Date of publication: 21.10.1998 Bulletin 1998/43 (21) Application number: 96908837.0 (22) Date of filing: 14.03.1996

(51) International Patent Classification (IPC):  C07K 14/ 60( . ) G01N 33/ 74( . ) G01N 33/ 50( . ) (86) International application number: PCT/US1996/003607 (87) International publication number: WO 1996/029002 (26.09.1996 Gazette 1996/43)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 17.03.1995 US 19950405842 (71) Applicant: UNIVERSITY OF SOUTH FLORIDA Tampa, FL 33620-7900 (US)	(72) Inventors: BERCU, Barry, B. Tampa, FL 33613 (US) WALKER, Richard, F. Indian Rocks Beach, FL 34635 (US) (74) Representative: Austin, Hedley William  Urquhart-Dykes & Lord Alexandra House 1 Alexandra Road Swansea Wales SA1 5ED Swansea Wales SA1 5ED (GB)