2,5-SUBSTITUTED ARYL PYRROLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE - Patent 0871444

(19)

(11)

EP 0 871 444 A1

(12)

(43)	Date of publication:
	21.10.1998 Bulletin 1998/43

(21)	Application number: 96928099.0

(22)	Date of filing: 06.08.1996

(51)

International Patent Classification (IPC):

A61K 31/ 00^{( . )}
A61K 31/ 4427^{( . )}
A61K 31/ 4433^{( . )}
A61K 31/ 445^{( . )}
A61K 31/ 4523^{( . )}
A61K 31/ 47^{( . )}
A61K 31/ 495^{( . )}
A61K 31/ 505^{( . )}
A61K 31/ 535^{( . )}
A61K 31/ 5377^{( . )}
A61P 1/ 04^{( . )}
A61P 19/ 00^{( . )}
A61P 31/ 00^{( . )}
A61P 43/ 00^{( . )}
C07D 401/ 14^{( . )}
C07D 405/ 14^{( . )}
C07D 413/ 14^{( . )}

A61K 31/ 44^{( . )}
A61K 31/ 443^{( . )}
A61K 31/ 4439^{( . )}
A61K 31/ 4465^{( . )}
A61K 31/ 4545^{( . )}
A61K 31/ 4709^{( . )}
A61K 31/ 496^{( . )}
A61K 31/ 506^{( . )}
A61K 31/ 5375^{( . )}
A61P 1/ 00^{( . )}
A61P 9/ 00^{( . )}
A61P 29/ 00^{( . )}
A61P 37/ 00^{( . )}
C07D 401/ 04^{( . )}
C07D 403/ 04^{( . )}
C07D 409/ 14^{( . )}
C07D 471/ 04^{( . )}

(86)	International application number:
	PCT/US1996/012922

(87)	International publication number:
	WO 1997/005878 (20.02.1997 Gazette 1997/09)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

(30)

Priority:

10.08.1995 US 19950002094
26.03.1996 US 19960014182
04.04.1996 GB 19960007253
25.04.1996 GB 19960008472

(71)	Applicant: MERCK & CO., INC.
	Rahway, New Jersey 07065 (US)

(72)	Inventors:
	DE LASZLO, Stephen, E. Rahway, NJ 07065 (US) MANTLO, Nathan, B. Rahway, NJ 07065 (US) PONTICELLO, Gerald, S. Rahway, NJ 07065 (US) SELNICK, Harold, G. Rahway, NJ 07065 (US) LIVERTON, Nigel, J. Rahway, NJ 07065 (US)

(74)	Representative: Thompson, John Dr., et al
	Merck & Co., Inc. European Patent Department Terlings Park Eastwick Road Harlow, Essex CM20 2QR Harlow, Essex CM20 2QR (GB)

(54)	2,5-SUBSTITUTED ARYL PYRROLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE