(19)

(11)

EP 0 871 445 A1

(12)

(43) Date of publication: 21.10.1998 Bulletin 1998/43 (21) Application number: 96943584.0 (22) Date of filing: 05.12.1996

(51) International Patent Classification (IPC):  C07D 513/ 04( . ) A61K 31/ 4155( . ) A61K 31/ 4353( . ) A61K 31/ 497( . ) A61K 31/ 5375( . ) A61K 31/ 54( . ) A61K 31/ 55( . ) A61P 25/ 04( . ) C07D 521/ 00( . ) A61K 31/ 00( . ) A61K 31/ 435( . ) A61K 31/ 437( . ) A61K 31/ 535( . ) A61K 31/ 5377( . ) A61K 31/ 541( . ) A61K 45/ 00( . ) A61P 43/ 00( . ) (86) International application number: PCT/US1996/019309 (87) International publication number: WO 1997/020561 (12.06.1997 Gazette 1997/25)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 07.12.1995 US 19950008299P (71) Applicant: ELI LILLY AND COMPANY Indianapolis, Indiana 46285 (US)	(72) Inventors: MITCH, Charles, H. Columbus, IN 47203 (US) SHANNON, Harlan, E. Carmel, IN 46033 (US) (74) Representative: Hudson, Christopher Mark, et al  Eli Lilly and Company Limited, Lilly Research Centre, Erl Wood Manor Windlesham Surrey GU20 6PH Windlesham Surrey GU20 6PH (GB)