(19)

(11)

EP 0 871 450 A1

(12)

(43) Date of publication: 21.10.1998 Bulletin 1998/43 (21) Application number: 97944242.0 (22) Date of filing: 24.09.1997

(51) International Patent Classification (IPC):  A61K 31/ 57( . ) A61K 31/ 00( . ) A61K 31/ 573( . ) A61P 11/ 00( . ) A61K 9/ 00( . ) A61K 31/ 165( . ) A61K 31/ 58( . ) A61P 11/ 06( . ) (86) International application number: PCT/SE1997/001606 (87) International publication number: WO 1998/015280 (16.04.1998 Gazette 1998/15)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: LT LV RO SI (30) Priority: 08.10.1996 SE 19960003669 (71) Applicant: Astra Aktiebolag 151 85 Södertälje (SE)	(72) Inventors: TROFAST, Jan S-226 47 Lund (SE) ULLMAN, Anders S-426 74 Västra Frölunda (SE)