(19)

(11)

EP 0 871 479 A2

(12)

(43) Date of publication: 21.10.1998 Bulletin 1998/43 (21) Application number: 96931208.0 (22) Date of filing: 31.05.1996

(51) International Patent Classification (IPC):  A61K( . ) A61K 39/ 09( . ) A61K 39/ 00( . ) (86) International application number: PCT/IB1996/001051 (87) International publication number: WO 1996/039113 (12.12.1996 Gazette 1997/02)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 02.06.1995 US 19950458399 07.06.1995 US 19950482981 30.05.1996 US 19960657751 (71) Applicant: THE UAB RESEARCH FOUNDATION Birmingham Alabama 35294 (US)	(72) Inventors: BRILES, David, E. Birmingham, AL 35222 (US) McDANIEL, Larry, S. Ridgeland, MS 39157 (US) YAMAMOTO, Masafumi Birmingham, AL 35242 (US) KIYONO, Hiroshi Birmingham, AL 35216 (US) (74) Representative: Harding, Charles Thomas  D. Young & Co. 21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)