(19)

(11)

EP 0 871 480 A1

(12)

(43) Date of publication: 21.10.1998 Bulletin 1998/43 (21) Application number: 97912648.0 (22) Date of filing: 02.10.1997

(51) International Patent Classification (IPC):  C07K 14/ 47( . ) A61K 38/ 00( . ) G01N 33/ 574( . ) A61K 39/ 00( . ) (86) International application number: PCT/US1997/015741 (87) International publication number: WO 1998/014206 (09.04.1998 Gazette 1998/14)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV RO SI (30) Priority: 04.10.1996 US 19960027002P (71) Applicant: THOMAS JEFFERSON UNIVERSITY Philadelphia Pennsylvania 19107 (US)	(72) Inventors: BERD, David Wyncote, PA 19095 (US) PARMIANI, Giorgio, Istituto Nazionale-Cura Tumori 20133 Milano (IT) ANICHINI, Andrea I-17-24044 Dalmine (IT) SENSI, Marialuisa I-6-20133 Milano (IT) (74) Representative: Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät  Maximilianstrasse 58 80538 München 80538 München (DE)