(19)
(11)
EP 0 871 481 A1
(12)
(43)
Date of publication:
21.10.1998
Bulletin 1998/43
(21)
Application number:
96940252.0
(22)
Date of filing:
23.10.1996
(51)
International Patent Classification (IPC):
A61K
39/
104
( . )
A61K
47/
48
( . )
A61P
15/
00
( . )
A61P
35/
00
( . )
C07K
14/
21
( . )
C07K
16/
26
( . )
A61K
31/
00
( . )
A61K
51/
00
( . )
A61P
15/
18
( . )
C07K
7/
23
( . )
C07K
14/
575
( . )
A61K
39/
00
( . )
(86)
International application number:
PCT/US1996/017008
(87)
International publication number:
WO 1997/015325
(
01.05.1997
Gazette 1997/19)
(84)
Designated Contracting States:
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
(30)
Priority:
27.10.1995
US 19950008018P
13.02.1996
GB 19960002878
(71)
Applicant:
MERCK & CO., INC.
Rahway, New Jersey 07065 (US)
(72)
Inventors:
HICKEY, Gerard, J.
Rahway, NJ 07065 (US)
MOHN, Kenneth, L.
Rahway, NJ 07065 (US)
(74)
Representative:
Hiscock, Ian James, et al
European Patent Department, Merck & Co., Inc., Terlings Park, Eastwick Road
Harlow, Essex CM20 2QR
Harlow, Essex CM20 2QR (GB)
(54)
PSEUDOMONAS EXOTOXIN AS IMMUNOGENIC CARRIER IN SYNTHETIC CONJUGATE VACCINES