(19)

(11)

EP 0 871 498 A1

(12)

(43) Date of publication: 21.10.1998 Bulletin 1998/43 (21) Application number: 96921384.0 (22) Date of filing: 07.06.1996

(51) International Patent Classification (IPC):  A61K 49/ 00( . ) B01J 13/ 02( . ) A61K 49/ 22( . ) (86) International application number: PCT/US1996/009547 (87) International publication number: WO 1996/040283 (19.12.1996 Gazette 1997/03)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 07.06.1995 US 19950477510 (71) Applicant: MOLECULAR BIOSYSTEMS, INC. San Diego California 92121 (US)	(72) Inventor: LOHRMANN, Rolff La Jolla, CA 92037 (US) (74) Representative: Goldin, Douglas Michael  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)