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(11)

EP 0 871 628 A1

(12)

(43) Date of publication: 21.10.1998 Bulletin 1998/43 (21) Application number: 96919103.0 (22) Date of filing: 05.06.1996

(51) International Patent Classification (IPC):  A61K 31/ 00( . ) A61K 31/ 505( . ) A61K 31/ 529( . ) A61P 31/ 04( . ) C07D 213/ 68( . ) C07D 471/ 04( . ) C07D 495/ 16( . ) C07K 5/ 06( . ) A61K 31/ 44( . ) A61K 31/ 519( . ) A61P 31/ 00( . ) C07D 213/ 61( . ) C07D 455/ 02( . ) C07D 491/ 16( . ) C07D 519/ 00( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1996/008991 (87) International publication number: WO 1996/039407 (12.12.1996 Gazette 1997/02)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 06.06.1995 US 19950469159 29.05.1996 US 19960638112 (71) Applicant: Abbott Laboratories Abbott Park, Illinois 60064-3500 (US)

(72) Inventors: CHU, Daniel, T. Santa Clara, CA 95051 (US) LI, Qun Gurnee, IL 60031 (US) COOPER, Curt, S. Gurnee, IL 60031 (US) FUNG, Anthony, K., L. Gurnee, IL 60031 (US) LEE, Cheuk, M. Libertyville, IL 60048 (US) PLATTNER, Jacob, J. Libertyville, IL 60048 (US) MA, Zhenkun Gurnee, IL 60031 (US) WANG, Wei-Bo Park City, IL 60085 (US) (74) Representative: Modiano, Guido, Dr.-Ing., et al  Modiano, Josif, Pisanty & Staub, Baaderstrasse 3 80469 München 80469 München (DE)