(19)

(11)

EP 0 871 639 A1

(12)

(43) Date of publication: 21.10.1998 Bulletin 1998/43 (21) Application number: 96936106.0 (22) Date of filing: 08.10.1996

(51) International Patent Classification (IPC):  C12P 19/ 60( . ) A61K 31/ 7042( . ) A61P 31/ 04( . ) C07H 19/ 01( . ) A61K 31/ 70( . ) A61K 31/ 7048( . ) C07H 17/ 04( . ) C12R 1/ 29( . ) (86) International application number: PCT/US1996/015750 (87) International publication number: WO 1997/013777 (17.04.1997 Gazette 1997/17)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE Designated Extension States: LT LV (30) Priority: 10.10.1995 US 19950005010P 21.02.1996 US 19960604692 (71) Applicant: SCHERING CORPORATION Kenilworth New Jersey 07033 (US)	(72) Inventors: MIERZWA, Ronald, A. Bloomfield, NJ 07003 (US) CHU, Min Union, NJ 07083 (US) JENKINS, John, K. Chatham, NJ 07928 (US) PATEL, Mahesh, G. Verona, NJ 07044 (US) (74) Representative: Ritter, Stephen David, et al  Mathys & Squire 100 Grays Inn Road London WC1X 8AL London WC1X 8AL (GB)