(19)

(11)

EP 0 871 641 A1

(12)

(43) Date of publication: 21.10.1998 Bulletin 1998/43 (21) Application number: 95917696.0 (22) Date of filing: 20.04.1995

(51) International Patent Classification (IPC):  C07K 16/ 24( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1995/005155 (87) International publication number: WO 1996/033204 (24.10.1996 Gazette 1996/47)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (71) Applicants: KENNEDY INSTITUTE OF RHEUMATOLOGY Hammersmith, London W6 8LH (GB) CENTOCOR, INC. Malvern, PA 19355-1307 (US)	(72) Inventors: FELDMANN, Marc London N6 4QT (GB) MAINI, Ravinder, Nath London SW13 9EW (GB) WOODY, James, N. West Chester, PA 19382 (US) (74) Representative: Holdcroft, James Gerald, Dr., et al  Graham Watt & Co. 3 Gray's Inn Square London WC1R 5AH London WC1R 5AH (GB)