(19)

(11)

EP 0 871 643 A1

(12)

(43) Date of publication: 21.10.1998 Bulletin 1998/43 (21) Application number: 96930490.0 (22) Date of filing: 17.07.1996

(51) International Patent Classification (IPC):  C07H 21/ 00( . ) A61K 38/ 00( . ) C12N 15/ 113( . ) (86) International application number: PCT/US1996/011786 (87) International publication number: WO 1997/003997 (06.02.1997 Gazette 1997/07)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 19.07.1995 US 19950001505 23.10.1995 US 19950535168 19.03.1996 US 19960013688 25.03.1996 US 19960014007 23.04.1996 US 19960016271 17.04.1996 US 19960015714 (71) Applicant: Aronex Pharmaceuticals, Inc. The Woodlands, TX 77381 (US)

(72) Inventors: RANDO, Robert, F. The Woodlands, TX 77380 (US) FENNEWALD, Susan The Woodlands, TX 77381 (US) ZENDEGUI, Joseph, G. The Woodlands, TX 77380 (US) OJWANG, Joshua, O. Spring, TX 77386 (US) HOGAN, Michael, E. The Woodlands, TX 77381 (US) POMMIER, Yves, Lab. of Molecular Pharmacology Bethesda, MD 20892 (US) MAZUMDER, Abhijit, Lab. of Molecular Pharmacology Bethesda, MD 20892 0892 (US) (74) Representative: Wise, Stephen James, et al  c/o RAWORTH, MOSS & COOK 36 Sydenham Road Croydon, Surrey CR0 2EF Croydon, Surrey CR0 2EF (GB)