(19)

(11)

EP 0 871 753 A2

(12)

(43) Date of publication: 21.10.1998 Bulletin 1998/43 (21) Application number: 96944812.0 (22) Date of filing: 13.12.1996

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C12N 7/ 00( . ) C12N 5/ 10( . ) C12N 15/ 867( . ) (86) International application number: PCT/US1996/019904 (87) International publication number: WO 1997/021824 (19.06.1997 Gazette 1997/26)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 15.12.1995 US 19950572959 15.12.1995 US 19950572943 (71) Applicant: SYSTEMIX, INC. Palo Alto, California 94304 (US)	(72) Inventors: RIGG, Richard, J. Mountain View, CA 94043 (US) DANDO, Jonathan, S. I-20132 Milano (IT) FORESTELL, Sean, P. Menlo Park, CA 94025 (US) BOHNLEIN, Ernst Los Altos, CA 94025 (US) (74) Representative: Gates, Marie Christina Esther, et al  c/o Tomkins & Co. 5 Dartmouth Road Dublin 6 Dublin 6 (IE)