(19)

(11)

EP 0 873 138 A2

(12)

(43) Date of publication: 28.10.1998 Bulletin 1998/44 (21) Application number: 96942490.0 (22) Date of filing: 19.12.1996

(51) International Patent Classification (IPC):  A61K 47/ 48( . ) C07K 14/ 11( . ) C07K 14/ 47( . ) C12N 7/ 04( . ) A61K 48/ 00( . ) C07K 14/ 025( . ) C07K 14/ 16( . ) C07K 16/ 28( . ) C12N 15/ 87( . ) (86) International application number: PCT/GB1996/003137 (87) International publication number: WO 1997/022363 (26.06.1997 Gazette 1997/27)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV RO SI (30) Priority: 19.12.1995 GB 19950025955 (71) Applicant: Therexsys Limited Keele, Staffordshire ST5 5SP (GB)	(72) Inventors: THATCHER, David, Robert Macclesfield Cheshire SK10 4XT (GB) OFFORD, Robin, Ewart CH-1239 Collex-Bossy (CH) ROSE, Keith CH-1208 Geneva (CH) GAERTNER, Hubert, François F-74160 Archamps (FR) (74) Representative: Hallybone, Huw George, et al  CARPMAELS AND RANSFORD 43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)