(19)

(11)

EP 0 873 360 A1

(12)

(43) Date of publication: 28.10.1998 Bulletin 1998/44 (21) Application number: 96902605.0 (22) Date of filing: 04.01.1996

(51) International Patent Classification (IPC):  C07K 14/ 495( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1996/000149 (87) International publication number: WO 1997/025349 (17.07.1997 Gazette 1997/31)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (71) Applicant: HUMAN GENOME SCIENCES, INC. Rockville, MD 20850-3338 (US)	(72) Inventor: WEI, Ying-Fei Darnestown, MD 20878 (US) (74) Representative: VOSSIUS & PARTNER  Postfach 86 07 67 81634 München 81634 München (DE)