(19)

(11)

EP 0 873 401 A1

(12)

(43) Date of publication: 28.10.1998 Bulletin 1998/44 (21) Application number: 96912159.0 (22) Date of filing: 03.05.1996

(51) International Patent Classification (IPC):  C07K 14/ 15( . ) A61K 39/ 00( . ) C12N 7/ 00( . ) (86) International application number: PCT/GB1996/001073 (87) International publication number: WO 1996/034942 (07.11.1996 Gazette 1996/49)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 05.05.1995 GB 19950009245 (71) Applicants: Griffiths, David John London N1 7BJ (GB) Weiss, Robert Anthony London N3 1SS (GB) Venables, Patrick John Woodgate London SW11 5PN (GB) Boyd, Mark Thomas Philadelphia, PA 19130 (US)	(72) Inventors: Griffiths, David John London N1 7BJ (GB) Weiss, Robert Anthony London N3 1SS (GB) Venables, Patrick John Woodgate London SW11 5PN (GB) Boyd, Mark Thomas Philadelphia, PA 19130 (US) (74) Representative: Kiddle, Simon John, et al  Mewburn Ellis, York House, 23 Kingsway London WC2B 6HP London WC2B 6HP (GB)