(19)
(11) EP 0 874 637 A1

(12)

(43) Date of publication:
04.11.1998 Bulletin 1998/45

(21) Application number: 97904780.0

(22) Date of filing: 16.01.1997
(51) International Patent Classification (IPC): 
G01N 33/ 566( . )
A61K 38/ 00( . )
A61K 45/ 00( . )
A61P 13/ 12( . )
C07K 16/ 18( . )
C12N 5/ 00( . )
C12P 21/ 08( . )
C12R 1/ 91( . )
 A61K 31/ 00( . )
A61K 39/ 395( . )
A61P 13/ 00( . )
C07K 14/ 705( . )
C07K 16/ 28( . )
C12N 15/ 02( . )
G01N 33/ 15( . )
(86) International application number:
PCT/US1997/000668
(87) International publication number:
WO 1997/026000 (24.07.1997 Gazette 1997/32)
(84) Designated Contracting States:
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 16.01.1996 US 19960587334
01.05.1996 US 19960641473

(71) Applicants:
  • The Trustees of Columbia University in the City of New York
    New York, NY 10027-6699 (US)
  • BIOGEN, INC.
    Cambridge Massachusetts 02142 (US)

(72) Inventors:
  • YELLIN, Michael, J.
    Riverdale, NY 10463 (US)
  • LEDERMAN, Seth
    New York, NY 10025 (US)
  • CHESS, Leonard
    Scarsdale, NY 10538 (US)
  • KARPUSAS, Mihail, N.
    Roslindale, MA 02131 (US)
  • THOMAS, David, W.
    Wellesley, MA 02181 (US)

(74) Representative: VOSSIUS & PARTNER 
Siebertstrasse 4
81675 München
81675 München (DE)

   


(54) THERAPEUTIC APPLICATIONS OF T-BAM (CD40L) TECHNOLOGY TO TREAT INFLAMMATORY KIDNEY DISEASES