(19)

(11)

EP 0 874 638 A1

(12)

(43) Date of publication: 04.11.1998 Bulletin 1998/45 (21) Application number: 96940437.0 (22) Date of filing: 12.11.1996

(51) International Patent Classification (IPC):  A61K 38/ 00( . ) A61P 7/ 00( . ) A61P 31/ 04( . ) A61P 31/ 12( . ) C07K 5/ 06( . ) A61K 31/ 00( . ) A61P 31/ 00( . ) A61P 31/ 10( . ) C07K 5/ 02( . ) (86) International application number: PCT/US1996/018245 (87) International publication number: WO 1997/017985 (22.05.1997 Gazette 1997/22)

(84) Designated Contracting States: BE CH DE ES FR GB IT LI NL (30) Priority: 13.11.1995 US 19950006474P (71) Applicants: SMITHKLINE BEECHAM CORPORATION King of Prussia, PA 19406-0939 (US) NYCOMED IMAGING AS 0401 Oslo 4 (NO)	(72) Inventors: BHATNAGAR, Pradip, Kumar Exton, PA 19341 (US) FISCHER, Peter, Martin N-0382 Oslo (NO) (74) Representative: Walker, Ralph Francis, Dr., et al  SmithKline Beecham plc Corporate Intellectual Property, Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)