(19)

(11)

EP 0 874 813 A1

(12)

(43) Date of publication: 04.11.1998 Bulletin 1998/45 (21) Application number: 96934788.0 (22) Date of filing: 23.10.1996

(51) International Patent Classification (IPC):  A61K 31/ 59( . ) A61P 35/ 00( . ) C07C 35/ 52( . ) C07F 7/ 18( . ) A61P 17/ 00( . ) A61P 35/ 02( . ) C07C 401/ 00( . ) (86) International application number: PCT/EP1996/004592 (87) International publication number: WO 1997/016423 (09.05.1997 Gazette 1997/20)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IE IT LI NL (30) Priority: 31.10.1995 US 19950007125P (71) Applicant: F. HOFFMANN-LA ROCHE AG 4002 Basel (CH)	(72) Inventors: IACOBELLI, Jerome, Anthony Paramus, NJ 07652 (US) USKOKOVIC, Milan, Radoje Upper Montclair, NJ 07043 (US) (74) Representative: Kjellsaa-Berger, Hanny, Dr., et al  Grenzacherstrasse 124, Postfach 3255 4070 Basel 4070 Basel (CH)