(19)

(11)

EP 0 874 828 A1

(12)

(43) Date of publication: 04.11.1998 Bulletin 1998/45 (21) Application number: 96942127.0 (22) Date of filing: 05.12.1996

(51) International Patent Classification (IPC):  A61K 31/ 41( . ) A61K 31/ 433( . ) A61K 31/ 44( . ) A61K 31/ 495( . ) A61K 31/ 55( . ) C07D 285/ 10( . ) C07D 453/ 02( . ) C07D 487/ 08( . ) A61K 31/ 4245( . ) A61K 31/ 439( . ) A61K 31/ 485( . ) A61K 31/ 497( . ) C07D 241/ 18( . ) C07D 417/ 12( . ) C07D 471/ 08( . ) (86) International application number: PCT/US1996/019229 (87) International publication number: WO 1997/020819 (12.06.1997 Gazette 1997/25)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE (30) Priority: 06.12.1995 US 19950009510P 06.12.1995 US 19950008280P 06.12.1995 US 19950008276P 06.12.1995 US 19950008279P 06.12.1995 US 19950008274P 06.12.1995 US 19950008273P 06.12.1995 US 19950008275P 06.12.1995 US 19950008270P (71) Applicant: ELI LILLY AND COMPANY Indianapolis, Indiana 46285 (US)	(72) Inventors: MITCH, Charles, H. Columbus, IN 47203 (US) SHANNON, Harlan, E. Carmel, IN 46234 (US) (74) Representative: Hudson, Christopher Mark, et al  Eli Lilly and Company Limited, Lilly Research Centre, Erl Wood Manor Windlesham Surrey GU20 6PH Windlesham Surrey GU20 6PH (GB)