(19)

(11)

EP 0 874 840 A1

(12)

(43) Date of publication: 04.11.1998 Bulletin 1998/45 (21) Application number: 96943126.0 (22) Date of filing: 16.12.1996

(51) International Patent Classification (IPC):  A61K 31/ 38( . ) C07D 337/ 14( . ) (86) International application number: PCT/EP1996/005631 (87) International publication number: WO 1997/023477 (03.07.1997 Gazette 1997/29)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 21.12.1995 GB 19950026264 (71) Applicant: KNOLL AKTIENGESELLSCHAFT D-67061 Ludwigshafen (DE)	(72) Inventors: COOPER, Stephen, Jason Belfast BT9 7BL (IE) KING, David, John Belfast BT9 7BL (IE) RANIWALLA, Joher Nottingham NG1 1GF (GB) (74) Representative: Karau, Wolfgang, Dr., et al  BASF Aktiengesellschaft, Patentabteilung ZDX - C 6 67056 Ludwigshafen 67056 Ludwigshafen (DE)