(19)

(11)

EP 0 874 901 A2

(12)

(43) Date of publication: 04.11.1998 Bulletin 1998/45 (21) Application number: 96941561.0 (22) Date of filing: 20.12.1996

(51) International Patent Classification (IPC):  C07K 14/ 47( . ) C12N 15/ 12( . ) C12N 9/ 16( . ) (86) International application number: PCT/CA1996/000867 (87) International publication number: WO 1997/022694 (26.06.1997 Gazette 1997/27)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 20.12.1995 GB 19950026036 19.03.1996 GB 19960005710 27.09.1996 GB 19960020265 (71) Applicant: Institute of Molecular and Cell Biology Singapore 117609 (SG)	(72) Inventors: PALLEN, Catherine, Jane Singapore 119260 (SG) CUI, Lin Singapore 119260 (SG) YU, Wei-Ping Singapore 119260 (SG) (74) Representative: Woods, Geoffrey Corlett  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)