(19)

(11)

EP 0 877 922 A1

(12)

(43) Date of publication: 18.11.1998 Bulletin 1998/47 (21) Application number: 97903878.0 (22) Date of filing: 22.01.1997

(51) International Patent Classification (IPC):  C12Q 3/ 00( . ) C12Q 1/ 02( . ) G05D 27/ 00( . ) C02F 3/ 30( . ) G01N 33/ 18( . ) (86) International application number: PCT/US1997/000931 (87) International publication number: WO 1997/026525 (24.07.1997 Gazette 1997/32)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB IE IT LI NL PT SE (30) Priority: 22.01.1996 US 19960589346 07.11.1996 US 19960746217 (71) Applicant: BIOCHEM TECHNOLOGY INC. King of Prussia, PA 19406 (US)	(72) Inventors: YANG, Xin Holland, PA 18966 (US) LEE, Jaw, Fang Berwyn, PA 19312 (US) MANESHIN, Sergey, K. Upper Holland, PA 19053 (US) MAH, Terrance, J. Cary, NC 27511 (US) (74) Representative: Klingseisen, Franz, Dipl.-Ing., et al  Patentanwälte, Dr. F. Zumstein, Dipl.-Ing. F. Klingseisen, Postfach 10 15 61 80089 München 80089 München (DE)