(19)
(11) EP 0 877 943 A1

(12)

(43) Date of publication:
18.11.1998 Bulletin 1998/47

(21) Application number: 96944987.0

(22) Date of filing: 23.12.1996
(51) International Patent Classification (IPC): 
A24D 3/ 06( . )
A24D 3/ 14( . )
A61K 31/ 425( . )
A61P 9/ 00( . )
C07D 277/ 20( . )
C07K 16/ 16( . )
G01N 33/ 543( . )
A24B 15/ 36( . )
A61K 31/ 00( . )
A61K 31/ 426( . )
A61P 9/ 10( . )
C07K 14/ 415( . )
G01N 33/ 53( . )
G01N 33/ 68( . )
(86) International application number:
PCT/US1996/020526
(87) International publication number:
WO 1997/023783 (03.07.1997 Gazette 1997/29)
(84) Designated Contracting States:
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
AL LT LV RO SI

(30) Priority: 26.12.1995 US 19950009218P
26.12.1995 US 19950009219P

(71) Applicants:
  • THE PICOWER INSTITUTE FOR MEDICAL RESEARCH
    Manhasset, NY 11030 (US)
  • ALTEON Inc.
    Ramsey, New Jersey 07446 (US)

(72) Inventors:
  • CERAMI, Anthony
    Shelter Island, NY 11964 (US)
  • BUCALA, Richard, J.
    Cos Cob, CT 06807 (US)
  • VLASSARA, Helen
    Shelter Island, NY 11964 (US)
  • FOUNDS, Henry, W.
    Mendham, NJ 07945 (US)
  • CERAMI, Clara J.
    New York, NY 10009 (US)

(74) Representative: Mercer, Christopher Paul, et al 
Carpmaels & Ransford 43, Bloomsbury Square
London WC1A 2RA
London WC1A 2RA (GB)

   


(54) METHODS FOR MEASUREMENT AND TREATMENT PREDICATED ON THE PRESENCE OF ADVANCED GLYCOSYLATION ENDPRODUCTS IN TOBACCO AND ITS COMBUSTION BYPRODUCTS