(19)

(11)

EP 0 879 055 A1

(12)

(43) Date of publication: 25.11.1998 Bulletin 1998/48 (21) Application number: 97905872.0 (22) Date of filing: 07.02.1997

(51) International Patent Classification (IPC):  A61K 45/ 00( . ) A61K 31/ 192( . ) A61K 31/ 385( . ) A61K 31/ 4425( . ) A61P 31/ 16( . ) A61K 31/ 19( . ) A61K 31/ 216( . ) A61K 31/ 4409( . ) A61P 31/ 12( . ) C12N 7/ 01( . ) (86) International application number: PCT/US1997/002052 (87) International publication number: WO 1997/028802 (14.08.1997 Gazette 1997/35)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE Designated Extension States: AL LT LV RO SI (30) Priority: 09.02.1996 US 19960011142P 06.05.1996 US 19960017119P (71) Applicant: ELI LILLY AND COMPANY Indianapolis, Indiana 46285 (US)

(72) Inventors: CALACINO, Joseph, M. Indianapolis, IN 46256 (US) HATCH, Steven, D. New Palestine, IN 46163 (US) HORNBACK, William, J. Fishers, IN 46038 (US) MUESING, Mark, A. New York, New York 10021 (US) MUNROE, John, E. Indianapolis, IN 46220 (US) STASCHKE, Kirk, A. Indianapolis, IN 46220 (US) TANG, Joseph, Chiou-Chung Carmel, IN 46033 (US) (74) Representative: Denholm, Anna Marie, et al  Eli Lilly and Company Limited, Lilly Research Center, Erl Wood Manor Windlesham, Surrey GU20 6PH Windlesham, Surrey GU20 6PH (GB)