(19)

(11)

EP 0 879 240 A1

(12)

(43) Date of publication: 25.11.1998 Bulletin 1998/48 (21) Application number: 95922961.0 (22) Date of filing: 05.06.1995

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 39/ 395( . ) A61P 35/ 00( . ) C07K 14/ 475( . ) C07K 16/ 22( . ) C12N 5/ 10( . ) C12P 21/ 08( . ) G01N 33/ 566( . ) A61K 39/ 02( . ) A61K 45/ 00( . ) A61P 43/ 00( . ) C07K 14/ 52( . ) C07K 16/ 24( . ) C12P 21/ 02( . ) C12Q 1/ 68( . ) (86) International application number: PCT/US1995/007087 (87) International publication number: WO 1996/039420 (12.12.1996 Gazette 1997/02)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (71) Applicant: HUMAN GENOME SCIENCES, INC. Rockville, MD 20850-3338 (US)	(72) Inventors: MEISSNER, Paul, S. Barnesville, MD 20838 (US) COLEMAN, Timothy, A. Gaithersberg, MD 20879 (US) (74) Representative: VOSSIUS & PARTNER  Postfach 86 07 67 81634 München 81634 München (DE)