(19)

(11)

EP 0 879 279 A1

(12)

(43) Date of publication: 25.11.1998 Bulletin 1998/48 (21) Application number: 97905834.0 (22) Date of filing: 06.02.1997

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 38/ 00( . ) A61P 3/ 10( . ) C12N 5/ 10( . ) A61K 35/ 76( . ) A61K 48/ 00( . ) C07K 14/ 605( . ) (86) International application number: PCT/US1997/001978 (87) International publication number: WO 1997/029180 (14.08.1997 Gazette 1997/35)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE Designated Extension States: RO (30) Priority: 06.02.1996 US 19960012111P 23.02.1996 GB 19960003847 (71) Applicant: ELI LILLY AND COMPANY Indianapolis, Indiana 46285 (US)

(72) Inventors: BORTS, Tracy, L. Indianapolis, IN 46220 (US) BRODERICK, Carol, L. Monrovia, IN 46157 (US) DIMARCHI, Richard, D. Carmel, IN 46033 (US) GRINNELL, Brian, W. Indianapolis, IN 46220 (US) MILLER, Anne, R. Indianapolis, IN 46208 (US) (74) Representative: Denholm, Anna Marie, et al  Eli Lilly and Company Limited, Lilly Research Center, Erl Wood Manor Windlesham, Surrey GU20 6PH Windlesham, Surrey GU20 6PH (GB)