(19)

(11)

EP 0 880 354 A1

(12)

(43) Date of publication: 02.12.1998 Bulletin 1998/49 (21) Application number: 97904914.0 (22) Date of filing: 06.02.1997

(51) International Patent Classification (IPC):  A61K 35/ 74( . ) A61K 36/ 05( . ) A61K 36/ 18( . ) A61K 36/ 8962( . ) A61P 13/ 02( . ) A61K 36/ 00( . ) A61K 36/ 14( . ) A61K 36/ 45( . ) A61P 1/ 12( . ) A61P 15/ 00( . ) (86) International application number: PCT/US1997/001662 (87) International publication number: WO 1997/029762 (21.08.1997 Gazette 1997/36)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 14.02.1996 US 19960601480 (71) Applicant: THE PROCTER & GAMBLE COMPANY Cincinnati, Ohio 45202 (US)	(72) Inventors: SAGEL, Paul, Joseph Maineville, OH 45039 (US) CARELLA, Anne, Marie Cincinnati, OH 45208 (US) (74) Representative: Clemo, Nicholas Graham, et al  Procter & Gamble Technical Centres Limited Patent Department Lovett House Lovett Road GB-Staines, Middlesex TW18 3AZ GB-Staines, Middlesex TW18 3AZ (GB)