(19)

(11)

EP 0 880 361 A1

(12)

(43) Date of publication: 02.12.1998 Bulletin 1998/49 (21) Application number: 97902552.0 (22) Date of filing: 17.02.1997

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C07K 14/ 18( . ) C07K 16/ 12( . ) C12N 1/ 19( . ) C12N 5/ 10( . ) A61K 39/ 00( . ) A61K 39/ 106( . ) C07K 14/ 28( . ) C12N 1/ 15( . ) C12N 1/ 21( . ) C12P 21/ 00( . ) (86) International application number: PCT/IB1997/000183 (87) International publication number: WO 1997/029771 (21.08.1997 Gazette 1997/36)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 16.02.1996 GB 19960003314 (71) Applicant: Chiron S.P.A. 53100 Siena (IT)	(72) Inventors: FONTANA, Maria, Rita Via Fiorentina, 1 I-53100 Siena (IT) PIZZA, Mariagrazia Via Fiorentina, 1 I-53100 Siena (IT) RAPPUOLI, Rino Via Fiorentina, 1 I-53100 Siena (IT) (74) Representative: Hallybone, Huw George, et al  CARPMAELS AND RANSFORD 43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)