(19)

(11)

EP 0 880 532 A1

(12)

(43) Date of publication: 02.12.1998 Bulletin 1998/49 (21) Application number: 97933585.0 (22) Date of filing: 22.01.1997

(51) International Patent Classification (IPC):  C07F 9/ 08( . ) A61K 31/ 661( . ) C07F 9/ 141( . ) C07F 9/ 145( . ) C07F 9/ 572( . ) C07F 9/ 6506( . ) C07F 9/ 6512( . ) C07F 9/ 655( . ) C07B 61/ 00( . ) A61K 31/ 66( . ) A61K 31/ 6615( . ) C07F 9/ 143( . ) C07F 9/ 24( . ) C07F 9/ 58( . ) C07F 9/ 6509( . ) C07F 9/ 6539( . ) C07F 9/ 6561( . ) (86) International application number: PCT/US1997/001060 (87) International publication number: WO 1997/028168 (07.08.1997 Gazette 1997/34)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 01.02.1996 US 19960595264 (71) Applicant: PHARMAGENICS, INC. Allendale, New Jersey 07401 (US)	(72) Inventors: GENTLES, Robert, G. Lake Bluff, IL 60043 (US) COOK, Alan, F. Cedar Grove, NJ 07009 (US) RUDOLPH, Morris, J. Boonton, NJ 07005 (US) FATHI, Reza Newark, NJ 07014 (US) (74) Representative: LOUIS, PÖHLAU, LOHRENTZ & SEGETH  Postfach 3055 90014 Nürnberg 90014 Nürnberg (DE)