METHODS OF ASSESSING MHC CLASS I EXPRESSION AND PROTEINS CAPABLE OF MODULATING CLASS I EXPRESSION

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EP 0 880 701 A1

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(43)	Date of publication:
	02.12.1998 Bulletin 1998/49

(21)	Application number: 96929056.0

(22)	Date of filing: 21.08.1996

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International Patent Classification (IPC):

C12N 15/ 09^{( . )}
A61K 48/ 00^{( . )}
A61P 37/ 06^{( . )}
C07K 14/ 74^{( . )}
C12N 15/ 00^{( . )}
C12P 21/ 08^{( . )}
C12Q 1/ 68^{( . )}
G01N 33/ 53^{( . )}
G01N 33/ 68^{( . )}

A61K 31/ 00^{( . )}
A61P 37/ 00^{( . )}
C07K 14/ 47^{( . )}
C07K 16/ 18^{( . )}
C12P 21/ 02^{( . )}
C12Q 1/ 26^{( . )}
G01N 33/ 15^{( . )}
G01N 33/ 566^{( . )}
C12R 1/ 91^{( . )}

(86)	International application number:
	PCT/US1996/013715

(87)	International publication number:
	WO 1997/007404 (27.02.1997 Gazette 1997/10)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

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Priority:

21.08.1995 US 19950503525

(71)	Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
	Rockville, MD 20852-3804 (US)

(72)	Inventors:
	KOHN, Leonard Bethesda, MD 20814 (US) SINGER, Dinah, S. Chevy Chase, MD 20815 (US) SAJI, Motoyasu Rockville, MD 20852 (US) GIULIANI, Cesidio Bethesda, MD 20817 (US) SHONG, Minho Rockville, MD 20852 (US) SUZUKI, Koichi Rockville, MD 20852 (US) OHMORI, Masayuki Rockville, MD 20852 (US)

(74)	Representative: Vossius, Volker, Dr., et al
	Dr. Volker Vossius, Patentanwaltskanzlei - Rechtsanwaltskanzlei, Holbeinstrasse 5 81679 München 81679 München (DE)

(54)	METHODS OF ASSESSING MHC CLASS I EXPRESSION AND PROTEINS CAPABLE OF MODULATING CLASS I EXPRESSION