(19)

(11)

EP 0 881 884 A1

(12)

(43) Date of publication: 09.12.1998 Bulletin 1998/50 (21) Application number: 96932169.0 (22) Date of filing: 06.09.1996

(51) International Patent Classification (IPC):  G01N 33/ 569( . ) A61K 39/ 02( . ) A61K 48/ 00( . ) C12N 9/ 04( . ) C12N 15/ 85( . ) A61K 35/ 74( . ) A61K 39/ 112( . ) C12N 1/ 21( . ) C12N 15/ 09( . ) (86) International application number: PCT/US1996/014190 (87) International publication number: WO 1997/008955 (13.03.1997 Gazette 1997/12)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 06.09.1995 US 19950003318 06.09.1995 US 19950523855 21.05.1996 US 19960018035 (71) Applicant: DEPARTMENT OF THE ARMY, US GOVERNMENT Frederick, MD 21702-5012 (US)	(72) Inventors: BRANSTROM, Arthur, A. Rockville, MD 20851 (US) SIZEMORE, Donata, R. Gaithersburg, MD 20879 (US) SADOFF, Jerald, C. Washington, DC 20012 (US) (74) Representative: Smart, Peter John  W.H. BECK, GREENER & CO 7 Stone Buildings Lincoln's Inn London WC2A 3SZ London WC2A 3SZ (GB)