ASPARTYL PROTEASE INHIBITORS - Patent 0882022

(19)

(11)

EP 0 882 022 A1

(12)

(43)	Date of publication:
	09.12.1998 Bulletin 1998/50

(21)	Application number: 97904911.0

(22)	Date of filing: 22.01.1997

(51)

International Patent Classification (IPC):

C07D 233/ 32^{( . )}
A61K 31/ 40^{( . )}
A61K 31/ 4015^{( . )}
A61K 31/ 403^{( . )}
A61K 31/ 41^{( . )}
A61K 31/ 4164^{( . )}
A61K 31/ 4192^{( . )}
A61K 31/ 427^{( . )}
A61K 31/ 435^{( . )}
A61K 31/ 437^{( . )}
A61K 31/ 472^{( . )}
A61K 31/ 495^{( . )}
A61K 31/ 505^{( . )}
A61K 31/ 535^{( . )}
A61K 31/ 5375^{( . )}
A61K 31/ 538^{( . )}
A61P 31/ 18^{( . )}
C07D 207/ 26^{( . )}
C07D 207/ 36^{( . )}
C07D 233/ 36^{( . )}
C07D 241/ 36^{( . )}
C07D 265/ 32^{( . )}
C07D 275/ 02^{( . )}
C07D 401/ 06^{( . )}
C07D 401/ 14^{( . )}
C07D 403/ 06^{( . )}
C07D 405/ 06^{( . )}
C07D 405/ 14^{( . )}
C07D 413/ 14^{( . )}
C07D 417/ 12^{( . )}
C07D 471/ 04^{( . )}
C07D 491/ 107^{( . )}
C07D 513/ 04^{( . )}

A61K 31/ 00^{( . )}
A61K 31/ 401^{( . )}
A61K 31/ 4025^{( . )}
A61K 31/ 407^{( . )}
A61K 31/ 415^{( . )}
A61K 31/ 4166^{( . )}
A61K 31/ 425^{( . )}
A61K 31/ 433^{( . )}
A61K 31/ 4353^{( . )}
A61K 31/ 47^{( . )}
A61K 31/ 4725^{( . )}
A61K 31/ 496^{( . )}
A61K 31/ 506^{( . )}
A61K 31/ 5365^{( . )}
A61K 31/ 5377^{( . )}
A61P 31/ 00^{( . )}
A61P 43/ 00^{( . )}
C07D 207/ 27^{( . )}
C07D 209/ 54^{( . )}
C07D 241/ 06^{( . )}
C07D 265/ 28^{( . )}
C07D 265/ 34^{( . )}
C07D 285/ 10^{( . )}
C07D 401/ 12^{( . )}
C07D 403/ 04^{( . )}
C07D 405/ 04^{( . )}
C07D 405/ 12^{( . )}
C07D 413/ 06^{( . )}
C07D 417/ 06^{( . )}
C07D 417/ 14^{( . )}
C07D 491/ 10^{( . )}
C07D 498/ 04^{( . )}

(86)	International application number:
	PCT/US1997/001610

(87)	International publication number:
	WO 1997/027180 (31.07.1997 Gazette 1997/33)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
	Designated Extension States:
	AL LT LV RO SI

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Priority:

26.01.1996 US 19960592777
30.09.1996 US 19960724563

(71)	Applicant: VERTEX PHARMACEUTICALS INCORPORATED
	Cambridge, MA 02139-4242 (US)

(72)	Inventors:
	TUNG, Roger, Dennis Arlington, MA 02174 (US) SALITURO, Francesco, Gerald Marlborough, MA 01752 (US) DEININGER, David, D. Arlington, MA 02174 (US) BHISETTI, Govinda, Rao Lexington, MA 02173 (US) BAKER, Christopher, Todd Waltham, MA 02154 (US) SPALTENSTEIN, Andrew Raleigh, NC 27606 (US) KAZMIERSKI, Wieslaw, M. Raleigh, NC 27615 (US) ANDREWS, Clarence, Webster, III Durham, NC 27704 (US)

(74)	Representative: VOSSIUS & PARTNER
	Siebertstrasse 4 81675 München 81675 München (DE)

(54)	ASPARTYL PROTEASE INHIBITORS