(19)
(11) EP 0 888 375 A1

(12)

(43) Date of publication:
07.01.1999 Bulletin 1999/01

(21) Application number: 97908799.0

(22) Date of filing: 28.02.1997
(51) International Patent Classification (IPC): 
G01N 33/ 53( . )
A61K 39/ 395( . )
A61K 49/ 00( . )
C07K 16/ 40( . )
C12N 9/ 64( . )
C12N 15/ 09( . )
G01N 33/ 573( . )
C12R 1/ 91( . )
A61K 38/ 55( . )
A61K 45/ 00( . )
A61P 29/ 00( . )
C12N 9/ 50( . )
C12N 15/ 00( . )
G01N 33/ 566( . )
A61K 38/ 00( . )
(86) International application number:
PCT/US1997/003217
(87) International publication number:
WO 1997/031931 (04.09.1997 Gazette 1997/38)
(84) Designated Contracting States:
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

(30) Priority: 01.03.1996 US 19960012679P

(71) Applicants:
  • THE PROCTER & GAMBLE COMPANY
    Cincinnati, Ohio 45202 (US)
  • CASE WESTERN RESERVE UNIVERSITY
    Cleveland, OH 44106-4946 (US)

(72) Inventors:
  • TINDAL, Michael, Howard
    Wyoming, OH 45215 (US)
  • HAQQI, Tariq
    Cleveland, OH 44106-4946 (US)

(74) Representative: Woof, Victoria, et al 
Procter & Gamble (Health & Beauty Care) Limited, Lovett House, Lovett Road
Staines, Middlesex TW18 3AZ
Staines, Middlesex TW18 3AZ (GB)

   


(54) A NOVEL DISINTEGRIN METALLOPROTEASE AND METHODS OF USE