(19)

(11)

EP 0 888 381 A1

(12)

(43) Date of publication: 07.01.1999 Bulletin 1999/01 (21) Application number: 96945796.0 (22) Date of filing: 19.12.1996

(51) International Patent Classification (IPC):  C12N 15/ 02( . ) A61K 38/ 00( . ) A61K 47/ 48( . ) A61P 7/ 00( . ) C07K 5/ 11( . ) C07K 16/ 18( . ) C12N 9/ 64( . ) C12N 15/ 09( . ) C12P 21/ 08( . ) A61K 31/ 00( . ) A61K 39/ 395( . ) A61K 49/ 00( . ) A61P 7/ 02( . ) C07K 14/ 745( . ) C07K 16/ 28( . ) C12N 9/ 72( . ) C12P 21/ 02( . ) (86) International application number: PCT/US1996/020577 (87) International publication number: WO 1997/039021 (23.10.1997 Gazette 1997/45)

(84) Designated Contracting States: BE CH DE DK FR GB IT LI NL SE (30) Priority: 21.12.1995 US 19950009028P (71) Applicant: The Scripps Research Institute La Jolla, CA 92037 (US)	(72) Inventors: MADISON, Edwin, L. Del Mar, CA 92014 (US) SMITH, Jeffrey, W. San Diego, CA 92130 (US) (74) Representative: Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät  Maximilianstrasse 58 80538 München 80538 München (DE)