(19)

(11)

EP 0 888 551 A1

(12)

(43) Date of publication: 07.01.1999 Bulletin 1999/01 (21) Application number: 97908256.0 (22) Date of filing: 17.03.1997

(51) International Patent Classification (IPC):  C12N 15/ 02( . ) C12N 5/ 00( . ) C12P 21/ 08( . ) G01N 33/ 577( . ) C07K 16/ 08( . ) C12N 5/ 10( . ) G01N 33/ 576( . ) C12R 1/ 91( . ) (86) International application number: PCT/EP1997/001351 (87) International publication number: WO 1997/035204 (25.09.1997 Gazette 1997/41)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 19.03.1996 EP 19960200758 (71) Applicant: Akzo Nobel N.V. 6824 BM Arnhem (NL)	(72) Inventors: PAULIJ, Wilhelmina, Petronella NL-5491 VD St. Oedenrode (NL) VAN ROOSMALEN, Markus, Hendrikus NL-5056 LH Berkel en Enschot (NL) HEIJTINK, Rudolf, Arnold NL-4285 WJ Woudrichem (NL) (74) Representative: Van Gent, Marieke  N.V. Organon, Postbus 20 5340 BH Oss 5340 BH Oss (NL)