(19)

(11)

EP 0 888 605 A1

(12)

(43) Date of publication: 07.01.1999 Bulletin 1999/01 (21) Application number: 96944427.0 (22) Date of filing: 13.12.1996

(51) International Patent Classification (IPC):  G10C 3/ 08( . ) (86) International application number: PCT/US1996/020089 (87) International publication number: WO 1997/022113 (19.06.1997 Gazette 1997/26)

(84) Designated Contracting States: DE FR GB (30) Priority: 14.12.1995 US 19950572866 (71) Applicant: THE UNIVERSITY OF CINCINNATI Cincinnati, OH 45267 (US)	(72) Inventors: WATHEN, Michael, J. Cincinnati, OH 45224 (US) HARRIS, Richard, L. Cincinnati, OH 45220 (US) (74) Representative: Hedley, Nicholas James Matthew  Stephenson Harwood One, St. Paul's Churchyard London EC4M 8SH London EC4M 8SH (GB)