(19)

(11)

EP 0 889 693 A1

(12)

(43) Date of publication: 13.01.1999 Bulletin 1999/02 (21) Application number: 97914765.0 (22) Date of filing: 20.02.1997

(51) International Patent Classification (IPC):  C12N 5/ 078( . ) C12N 5/ 0783( . ) (86) International application number: PCT/US1997/002309 (87) International publication number: WO 1997/030590 (28.08.1997 Gazette 1997/37)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 21.02.1996 US 19960604728 (71) Applicant: Cira Technologies Inc. Columbus, OH 43235 (US)	(72) Inventors: OLSEN, Richard, G. Montrose, CO 81401 (US) RIDIHALGH, John, L. Columbus, OH 43201 (US) (74) Representative: Weydert, Robert, et al  Dennemeyer & Associates Sàrl P.O. Box 1502 1015 Luxembourg 1015 Luxembourg (LU)