PHOSPHORAMIDATES AND PHOSPHINIC AMIDES, THEIR USE TO MODULATE THE ACTIVITY OF ENDOTHELIN - Patent 0889894

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(11)

EP 0 889 894 A1

(12)

(43)	Date of publication:
	13.01.1999 Bulletin 1999/02

(21)	Application number: 97915161.0

(22)	Date of filing: 18.03.1997

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International Patent Classification (IPC):

A61K 31/ 00^{( . )}
A61K 31/ 661^{( . )}
A61K 31/ 664^{( . )}
A61P 9/ 00^{( . )}
A61P 9/ 12^{( . )}
A61P 11/ 06^{( . )}
A61P 13/ 12^{( . )}
A61P 17/ 02^{( . )}
A61P 29/ 00^{( . )}
A61P 43/ 00^{( . )}
C07F 9/ 44^{( . )}
C07F 9/ 6512^{( . )}
C07F 9/ 6539^{( . )}

A61K 31/ 66^{( . )}
A61K 31/ 6615^{( . )}
A61P 1/ 00^{( . )}
A61P 9/ 10^{( . )}
A61P 11/ 00^{( . )}
A61P 11/ 08^{( . )}
A61P 15/ 00^{( . )}
A61P 27/ 02^{( . )}
A61P 37/ 06^{( . )}
C07F 9/ 24^{( . )}
C07F 9/ 6509^{( . )}
C07F 9/ 653^{( . )}

(86)	International application number:
	PCT/US1997/004364

(87)	International publication number:
	WO 1997/035864 (02.10.1997 Gazette 1997/42)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
	Designated Extension States:
	AL LT LV RO SI

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Priority:

26.03.1996 US 19960624706

(71)	Applicant: TEXAS BIOTECHNOLOGY CORPORATION
	Houston, TX 77030 (US)

(72)	Inventors:
	CHAN, Ming, F. Encinitas, CA 92024 (US) VERNER, Erik, J. Foster City, CA 94404 (US)

(74)	Representative: Goldin, Douglas Michael, et al
	J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)

(54)	PHOSPHORAMIDATES AND PHOSPHINIC AMIDES, THEIR USE TO MODULATE THE ACTIVITY OF ENDOTHELIN