(19)

(11)

EP 0 891 190 A2

(12)

(43) Date of publication: 20.01.1999 Bulletin 1999/03 (21) Application number: 97950577.0 (22) Date of filing: 31.10.1997

(51) International Patent Classification (IPC):  A61K 9/ 14( . ) A61K 47/ 38( . ) A61K 47/ 10( . ) (86) International application number: PCT/US1997/019831 (87) International publication number: WO 1998/019708 (14.05.1998 Gazette 1998/19)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 04.11.1996 US 19960030282P (71) Applicant: UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION Danbury, Connecticut 06817-0001 (US)	(72) Inventors: DONABEDIAN, David, H. Somerset, NJ 08873 (US) MARLIN, Lawrence Bridgewater, NJ 08807 (US) CLARK, Elke, M., A. Ringoes, NJ 08551 (US) (74) Representative: Hayes, Adrian Chetwynd, et al  Boult Wade Tennant, 27 Furnival Street London EC4A 1PQ London EC4A 1PQ (GB)