(19)
(11) EP 0 891 338 A1

(12)

(43) Date of publication:
20.01.1999 Bulletin 1999/03

(21) Application number: 97907685.0

(22) Date of filing: 04.03.1997
(51) International Patent Classification (IPC): 
A61K 31/ 00( . )
A61K 47/ 48( . )
A61P 9/ 00( . )
A61P 39/ 00( . )
A61P 43/ 00( . )
C07F 13/ 00( . )
 A61K 31/ 555( . )
A61P 1/ 00( . )
A61P 9/ 10( . )
A61P 39/ 06( . )
C07D 259/ 00( . )
C07F 15/ 02( . )
(86) International application number:
PCT/US1997/002566
(87) International publication number:
WO 1997/033877 (18.09.1997 Gazette 1997/40)
(84) Designated Contracting States:
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

(30) Priority: 13.03.1996 US 19960013348P
14.08.1996 WO 1996US12767

(71) Applicant: MONSANTO COMPANY
St. Louis, Missouri 63167 (US)

(72) Inventors:
  • NEUMANN, William, L.
    Kirkwood, MO 63122 (US)
  • RILEY, Dennis, P.
    Ballwin, MO 63011 (US)
  • WEISS, Randy, H.
    St. Louis, MO 63129 (US)
  • HENKE, Susan, L.
    Webster Grove, MO 63119 (US)
  • LENNON, Patrick, J.
    Clayton, MO 63105 (US)
  • ASTON, Karl, W.
    Pacific, MO 63069 (US)

(74) Representative: Beil, Hans Christoph, Dr,, et al 
Hansmann & Vogeser Patent- und Rechtsanwälte Postfach 80 0140
65901 Frankfurt am Main
65901 Frankfurt am Main (DE)

   


(54) BIOCONJUGATES OF MANGANESE OR IRON COMPLEXES OF NITROGEN-CONTAINING MACROCYCLIC LIGANDS EFFECTIVE AS CATALYSTS FOR DISMUTATING SUPEROXIDE