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(11)

EP 0 894 005 A1

(12)

(43) Date of publication: 03.02.1999 Bulletin 1999/05 (21) Application number: 97906536.0 (22) Date of filing: 13.02.1997

(51) International Patent Classification (IPC):  A61K 39/ 02( . ) C07K 14/ 255( . ) A61K 39/ 00( . ) A61K 39/ 112( . ) C12N 1/ 21( . ) (86) International application number: PCT/US1997/002074 (87) International publication number: WO 1997/029768 (21.08.1997 Gazette 1997/36)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 15.02.1996 US 19960601790 (71) Applicant: THE BOARD OF GOVERNORS FOR HIGHER EDUCATION STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS Providence, RI 02908 (US)	(72) Inventors: COHEN, Paul, S. Kingston, RI 02881 (US) LAUX, David, C. Kingston, RI 02881 (US) FRANKLIN, David, P. Boston, MA 02109 (US) (74) Representative: Bankes, Stephen Charles Digby, et al  BARON & WARREN 18 South End Kensington London W8 5BU London W8 5BU (GB)