(19)

(11)

EP 0 894 127 A2

(12)

(43) Date of publication: 03.02.1999 Bulletin 1999/05 (21) Application number: 97915222.0 (22) Date of filing: 11.04.1997

(51) International Patent Classification (IPC):  A61K 9/ 00( . ) C12N 5/ 071( . ) A61K 9/ 16( . ) A61K 35/ 12( . ) (86) International application number: PCT/CA1997/000231 (87) International publication number: WO 1997/039107 (23.10.1997 Gazette 1997/45)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 12.04.1996 US 19960015310P 14.06.1996 US 19960019737P (71) Applicant: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA Edmonton, Alberta T6G 2E1 (CA)	(72) Inventors: KORBUTT, Gregory Edmonton, Alberta T6H 3R5 (CA) RAJOTTE, Ray Edmonton, Alberta T6W 1A9 (CA) (74) Representative: Thomson, Paul Anthony  Potts, Kerr & Co. 15, Hamilton Square Birkenhead Merseyside L41 6BR Birkenhead Merseyside L41 6BR (GB)