(19)

(11)

EP 0 895 541 A1

(12)

(43) Date of publication: 10.02.1999 Bulletin 1999/06 (21) Application number: 97917358.0 (22) Date of filing: 18.04.1997

(51) International Patent Classification (IPC):  C12N 9/ 10( . ) A61K 39/ 00( . ) C12N 15/ 65( . ) (86) International application number: PCT/GB1997/001080 (87) International publication number: WO 1997/040169 (30.10.1997 Gazette 1997/46)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 19.04.1996 GB 19960008106 (71) Applicant: MEDEVA EUROPE LIMITED London SW1A 1EF (GB)	(72) Inventors: KHAN, Mohammed, Anjam Newcastle upon Tyne NE2 4HE (GB) McNEIL, Hesta, Varey Newcastle upon Tyne NE2 4HH (GB) HORMAECHE, Carlos, Estenio Newcastle upon Tyne NE2 4HH (GB) (74) Representative: Woods, Geoffrey Corlett  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)